The Eleven Approach: An Integrated and Holistic View of Protein Design

At Eleven, we apply an integrated and holistic view of protein drug discovery and development to create novel protein designs that expand beyond simple protein engineering to create innovative solutions for complex biologic, medical, and commercial challenges. First, we envision an optimal target product profile with specific characteristics based on market need, such as improved physical, pharmaceutical, and therapeutic benefits. Second, we rationally designs protein therapeutics to the specific product profile with access to unlimited structural formats using molecular modeling, computational approaches and molecular evolution; all built around a comprehensive understanding of how proteins interact biologically with their targets. Finally, we utilize multiple tools and rapid testing of ideas and concepts to make quick decisions with the advantage of reduced early-stage development timelines.

AMP-Rx Eleven’s proprietary product engine is called AMP-Rx and is comprised of the following components:

A = Accelerated creation. Our rational protein design approach enables accelerating early-stage development timelines by leveraging multiple tools and rapid testing of ideas and concepts.

M = Multi-faceted approach. We are integrating many facets of protein design with a holistic view; from designing the optimal product profile based on market need, to the selection of tools and techniques that best fit therapeutic specifications.

P = Product focus. Our steadfast goal is to create differentiated, best-in-class products with superior therapeutic effects.

Rx = Rationally designed therapeutics. The thrust of our product engine is the rational design of first-of-a-kind protein structures that achieve an optimal target product profile for superior properties and improved therapeutic outcomes.